Article

Structural basis of human PRPS2 filaments

2022-07-11

Abstract excerpt

<h4>ABSTRACT</h4> PRPP synthase (PRPS) transfers the pyrophosphate groups from ATP to ribose-5-phosphate to produce 5-phosphate ribose-1-pyrophosphate (PRPP), a key intermediate in the biosynthesis of several metabolites including nucleotides, dinucleotides and some amino acids. There are three PRPS isoforms encoded in human genome. While hPRPS1 and hPRPS2 are expressed in most tissues, hPRPS3 is exclusively expr...

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Literature Corpus work: f3c73913-5c6e-51de-89e2-0f7eed62e7bb
DOI: 10.1101/2022.07.11.499506

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