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Article

Human PRPS1 filaments stabilize allosteric sites to regulate activity.

Nature structural & molecular biology - 1 Mar 2023

Hvorecny Kelli L, Hargett Kenzee, Quispe Joel D, Kollman Justin M

Abstract excerpt

The universally conserved enzyme phosphoribosyl pyrophosphate synthetase (PRPS) assembles filaments in evolutionarily diverse organisms. PRPS is a key regulator of nucleotide metabolism, and mutations in the human enzyme PRPS1 lead to a spectrum of diseases. Here we determine structures of human PRPS1 filaments in active and inhibited states, with fixed assembly contacts accommodating both conformations. The...

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Identifiers

PMID: 36747094
DOI: 10.1038/s41594-023-00921-z
PMCID: PMC10033377

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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