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Article

Stabilization of glucose-6-phosphate dehydrogenase oligomers enhances catalytic activity and stability of clinical variants.

The Journal of biological chemistry - 1 Mar 2022

Garcia Adriana Ann, Mathews Irimpan I, Horikoshi Naoki, Matsui Tsutomu, Kaur Manat, Wakatsuki Soichi, Mochly-Rosen Daria

Abstract excerpt

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is a genetic trait that can cause hemolytic anemia. To date, over 150 nonsynonymous mutations have been identified in G6PD, with pathogenic mutations clustering near the dimer and/or tetramer interface and the allosteric NADP+-binding site. Recently, our lab identified a small molecule that activates G6PD variants by stabilizing the allosteric NADP+ and dimer...

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Identifiers

PMID: 35065072
DOI: 10.1016/j.jbc.2022.101610
PMCID: PMC8861134

Genes

G6PD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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