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<i>In vitro</i> -generated inflammatory fibroblasts secrete extracellular matrix with biochemical and biophysical properties similar to tissue-remodelling fibroblasts

2024-09-26

Abstract excerpt

In solid cancers, inflammation and viral infections, two main fibroblast subtypes have been identified: myofibroblast-like fibroblasts and inflammatory fibroblasts. In the tumour microenvironment (TME), these cancer-associated fibroblast (CAF) subtypes are known as myCAFs, which generate a stiffened fibrotic extracellular matrix (ECM), and iCAFs, which secrete inflammatory cytokines to locally modulate the immune...

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Literature Corpus work
15639039-24df-5a8a-871e-dd266291e6a0
DOI
10.1101/2024.09.26.614950
Open publication

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<i>In vitro</i> -generated inflammatory fibroblasts secrete extracellular matrix with biochemical and biophysical properties similar to tissue-remodelling fibroblastsDOI 10.1101/2024.09.26.614950
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