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Article

Diversity and Biology of Cancer-Associated Fibroblasts

28 May 2020

Abstract excerpt

Efforts to develop anti-cancer therapies have largely focused on targeting the epithelial compartment, despite the presence of non-neoplastic stromal components that substantially contribute to the progression of the tumor. Indeed, cancer cell survival, growth, migration, and even dormancy are influenced by the surrounding tumor microenvironment (TME). Within the TME, cancer-associated fibroblasts (CAFs) have...

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PMID: 32466724
DOI: 10.1152/physrev.00048.2019

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