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Cancer-associated Fibroblast Spatial Heterogeneity and <i>EMILIN1</i> Expression in Cancer Stroma Modulate TGF-β Activity and CD8 <sup>+</sup> T-Cell Infiltration in Breast Cancer

2023-09-15

Abstract excerpt

<h4>ABSTRACT</h4> The tumor microenvironment (TME) and its multifaceted interactions with cancer cells are major targets for cancer treatment. Single-cell technologies have brought major insights into the TME, but the resulting complexity frequently precludes conclusions on function. Therefore, we combined single-cell RNA sequencing and spatial transcriptomic data to explore the relationship between different can...

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Literature Corpus work
76789590-d7c6-508d-bfc1-ed38cb17a786
DOI
10.1101/2023.09.12.557312
Open publication

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Cancer-associated Fibroblast Spatial Heterogeneity and <i>EMILIN1</i> Expression in Cancer Stroma Modulate TGF-β Activity and CD8 <sup>+</sup> T-Cell Infiltration in Breast CancerDOI 10.1101/2023.09.12.557312
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