Article

Single cell and spatial analysis of immune-hot and immune-cold tumours identifies fibroblast subtypes associated with distinct immunological niches and positive immunotherapy response

2024-12-09

Abstract excerpt

<title>Abstract</title> <p>Cancer-associated Fibroblasts (CAFs) have emerged as critical regulators of anti-tumour immunity, with both beneficial and detrimental properties that remain poorly characterised. To investigate this, we performed single-cell and spatial transcriptomic analysis, comparing immune-hot and immune-cold HNSCC subgroups (human papillomavirus [HPV] + ve and HPV-ve tumours respectively). This i...

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Literature Corpus work: 5af49ab9-3c8d-5e2b-97fa-46f5766ec2ad
DOI: 10.21203/rs.3.rs-5125055/v1

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