Article

Single-cell transcriptome analysis reveals evolutionarily conserved features during the transition from normal breast stromal cells to cancer-associated fibroblasts

2022-05-05

Abstract excerpt

<h4>Summary</h4> To comprehend cancer-associated fibroblasts (CAFs) origins, single-cell RNA sequencing was conducted on normal and cancerous breast tissue from mice and humans. We found three conserved CAF subtypes, which based on GOterm analysis we designated as matrix CAFs-, chemokine CAFs, and contractile CAFs. Matrix and chemokine CAFs originated from resident fibroblasts, while contractile CAFs originated f...

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Literature Corpus work: cb9f517f-bdb1-5e4f-85a3-d409ff19cee6
DOI: 10.1101/2022.05.05.490693

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