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Cross-tissue human fibroblast atlas reveals myofibroblast subtypes with distinct roles in immune modulation

19 Sept 2024

Abstract excerpt

Fibroblasts, known for their functional diversity, play crucial roles in inflammation and cancer. In this study, we conduct comprehensive single-cell RNA sequencing analyses on fibroblast cells from 517 human samples, spanning 11 tissue types and diverse pathological states. We identify distinct fibroblast subpopulations with universal and tissue-specific characteristics. Pathological conditions lead to...

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PMID: 39303725
DOI: 10.1016/j.ccell.2024.08.020

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