Article

A fibroblast-centric network drives cold fibrosis in the tumor microenvironment of lung squamous cell carcinoma

2025-08-25

Abstract excerpt

The tumor microenvironment (TME) of chronic inflammation-associated cancers (CIACs) is shaped by cycles of injury and maladaptive repair, yet the principles organizing fibrotic stroma in these tumors remain unclear. Here, we applied the concept of hot versus cold fibrosis, originally credentialed in non-cancerous fibrosis of heart and kidney, to lung squamous cell carcinoma (LUSC), a prototypical CIAC. Single-cell...

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Literature Corpus work: f5940504-2cf8-5969-8d04-1ab85869d0f6
DOI: 10.1101/2025.08.25.668405

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