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Cancer Associated Fibroblasts: The Architects of Stroma Remodeling

27 Dec 2017

Abstract excerpt

Fibroblasts have exceptional phenotypic plasticity and capability to secrete vast amount of soluble factors, extracellular matrix components and extracellular vesicles. While in physiological conditions this makes fibroblasts master regulators of tissue homeostasis and healing of injured tissues, in solid tumors cancer associated fibroblasts (CAFs) co-evolve with the disease, and alter the biochemical and...

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PMID: 29280568
DOI: 10.1002/pmic.201700167

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