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Cancer-Associated Fibroblasts in Solid Tumors and Sarcomas: Heterogeneity, Function, and Therapeutic Implications

2025-08-06

Abstract excerpt

Cancer-associated fibroblasts (CAFs) are crucial regulators of the tumor microenvironment (TME), promoting cancer progression, immune suppression, and therapy resistance. Single-cell transcriptomics has identified at least five distinct CAF subtypes—myofibroblastic (myCAFs), inflammatory (iCAFs), antigen-presenting (apCAFs), metabolic (meCAFs), and vascular/developmental (vCAFs/dCAFs)—each with unique localization...

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Literature Corpus work
a0c1bdb9-5e0a-505e-a7d7-e7304d640ca1
DOI
10.20944/preprints202508.0327.v1
Open publication

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