Article

Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four chronic inflammatory diseases

2021-01-12

Abstract excerpt

<h4>Summary</h4> Pro-inflammatory fibroblasts are critical to pathogenesis in rheumatoid arthritis, inflammatory bowel disease, interstitial lung disease, and Sjögren’s syndrome, and represent a novel therapeutic target for chronic inflammatory disease. However, the heterogeneity of fibroblast phenotypes, exacerbated by the lack of a common cross-tissue taxonomy, has limited the understanding of which pathways ar...

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Literature Corpus work: 7de2a4ec-9136-5e66-85ba-857b243b0b0f
DOI: 10.1101/2021.01.11.426253

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