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Trapped Topoisomerase II initiates formation of <i>de novo</i> duplications <i>via</i> the nonhomologous end-joining pathway in yeast

2020-05-04

Abstract excerpt

<h4>ABSTRACT</h4> Topoisomerase II (Top2) is an essential enzyme that resolves catenanes between sister chromatids as well as supercoils associated with the over- or under-winding of duplex DNA. Top2 alters DNA topology by making a double-strand break (DSB) in DNA and passing an intact duplex through the break. Each component monomer of the Top2 homodimer nicks one of the DNA strands and forms a covalent phosphot...

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Literature Corpus work
fa52c7df-e98b-50ad-8a52-e09099682801
DOI
10.1101/2020.05.03.075358
Open publication

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Trapped Topoisomerase II initiates formation of <i>de novo</i> duplications <i>via</i> the nonhomologous end-joining pathway in yeastDOI 10.1101/2020.05.03.075358
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