Article

Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNA

2023-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Inherited and de novo copy number variants (CNVs) are increasingly found to be correlated with human developmental and cancerous phenotypes. Several models for template switching during replication have been proposed to explain the generation of these gross chromosomal rearrangements. We proposed a model of template switching (ODIRA—origin dependent inverted repeat amplification) in which simul...

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Literature Corpus work: 0907af1d-51f1-5822-ba20-b9328768c2cf
DOI: 10.1101/2023.07.03.547456

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Template switching between the leading and lagging strands at replication forks generates inverted copy number variants through hairpin-capped extrachromosomal DNADOI 10.1101/2023.07.03.547456Read

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