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Article

Age-dependent tumor-immune interactions underlie immunotherapy response in pediatric cancer

2025-07-18

Abstract excerpt

<h4>SUMMARY</h4> Pediatric cancers originate in rapidly growing tissues within the context of a developing host. However, the interactions between cancer cells and the developing immune system are incompletely understood. Here, we established a suite of pediatric syngeneic mouse cancer models across diverse anatomical sites and compared their tumor immune microenvironment with that in adult mice. Tumors in pediat...

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Identifiers and source

Literature Corpus work
1536d424-78d0-5b4d-9cb4-d237de56a900
DOI
10.1101/2025.07.16.663652
Open publication

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Age-dependent tumor-immune interactions underlie immunotherapy response in pediatric cancerDOI 10.1101/2025.07.16.663652
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