Article

Efficacy of DNA Methyltransferase Inhibitor Immune Priming Therapy in Combination with PD-1 Inhibitors to Treat High-Risk Pediatric Brain Tumors

2025-05-18

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Despite intensive therapies, outcomes for high-risk pediatric brain tumors (PBTs) remain dismal, prompting the search for novel treatments. DNA methyltransferase inhibitors (DNMTi) have been shown to prime tumors to improve response to checkpoint inhibition. The aim of this study was to investigate the potential of decitabine (DAC), in combination with a PD-1 inhibitor, to i...

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Literature Corpus work: 053df8f0-d78f-5fd2-939c-18180a1e0d69
DOI: 10.1101/2025.05.14.654106

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