Article

Differential Assembly of Mouse and Human Tumor Microenvironments

2025-07-05

Abstract excerpt

<h4>Summary</h4> Mouse models are frequently used to develop treatments for human cancer. Yet, we lack a comprehensive understanding of the comparative organization of mouse and human tumor microenvironments (mu/huTMEs). Through immunoprofiling of commonly used mouse models, we found that the immune composition of most muTMEs resemble poorly infiltrated human tumors extensively biased toward high macrophages dens...

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Literature Corpus work: bb25c843-bbd9-531f-811f-24ce8a068f5f
DOI: 10.1101/2025.07.01.661217

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