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Article

Antigen cross-presentation in young tumor-bearing hosts promotes CD8 + T cell terminal differentiation

4 Feb 2022

Abstract excerpt

The immune system undergoes a progressive functional remodeling with age. Understanding how age bias shapes antitumor immunity is essential in designing effective immunotherapies, especially for pediatric patients. Here, we explore antitumor CD8 + T cell responses generated in young (prepubescent) and adult (presenescent) mice. Using an MHCI-deficient tumor model, we observed that tumor-reactive CD8 + T cells...

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PMID: 35119937
DOI: 10.1126/sciimmunol.abf6136

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