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Article

Assessment of programmed death‐ligand 1 expression and tumor‐associated immune cells in pediatric cancer tissues

13 Jun 2017

Abstract excerpt

BACKGROUND: Programmed death 1 (PD-1) signaling in the tumor microenvironment dampens immune responses to cancer, and blocking this axis induces antitumor effects in several malignancies. Clinical studies of PD-1 blockade are only now being initiated in pediatric patients, and little is known regarding programmed death-ligand 1 (PD-L1) expression in common childhood cancers. The authors characterized PD-L1...

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PMID: 28608950
DOI: 10.1002/cncr.30724

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