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Article

Single-cell transcriptomics reveals shared immunosuppressive landscapes of mouse and human neuroblastoma

1 Aug 2022

Abstract excerpt

BACKGROUND: High-risk neuroblastoma is a pediatric cancer with still a dismal prognosis, despite multimodal and intensive therapies. Tumor microenvironment represents a key component of the tumor ecosystem the complexity of which has to be accurately understood to define selective targeting opportunities, including immune-based therapies. METHODS: We combined various approaches including single-cell...

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PMID: 36054452
DOI: 10.1136/jitc-2022-004807

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