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Immune profiling of pediatric germ cell tumors identifies key cell populations and novel therapeutic targets

20 Jun 2025

Abstract excerpt

Introduction Pediatric germ cell tumors (GCTs) are rare malignancies, comprising only about 3% of childhood cancers. Despite surgery and platinum-based chemotherapy being mainstays of treatment, their effectiveness varies by tumor subtype, and long-term toxicities remain a concern. We therefore explored the immune landscape of pediatric GCTs to uncover subtype-specific immunological features and identify...

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PMID: 40621458
DOI: 10.3389/fimmu.2025.1579948

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