A structure-guided approach to noncoding variant evaluation for transcription factor binding using AlphaFold 3.

Abstract excerpt

Noncoding single-nucleotide variants (SNVs) that alter transcription factor (TF) binding can affect gene expression and contribute to disease. Sequence-based methods can excel at predicting TF binding, but rely on training data and can exhibit TF-specific biases. Here, we propose a structure-guided approach for noncoding SNVs, using AlphaFold 3 (AF3) to model TF-DNA complexes and FoldX for downstream...

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• Share to Binding Sites
• Share to DNA
• Share to PAX5 gene