Article

Structural insights into FOXP2 multimerization and interactions from AlphaFold3 modeling

2025-04-27

Abstract excerpt

FOXP2 is a transcription factor critical for speech and language, yet its full-length structure remains unresolved experimentally. We used AlphaFold3 to model full-length human FOXP2 and its complexes. AlphaFold3 predicts that FOXP2 forms a symmetric homo-hexamer, in which oligomerization orders regions that are disordered in the monomer. This assembly may facilitate cooperative DNA binding via the forkhead DNA-bi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 4c0c9b58-8fbc-511c-abc9-f2ded115ed09
DOI: 10.1101/2025.04.25.650520

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structural insights into FOXP2 multimerization and interactions from AlphaFold3 modelingDOI 10.1101/2025.04.25.650520Read

Structural and biological features of FOXP3 dimerization relevant to regulatory T cell function.Semantic proximity Read

Structure of the forkhead domain of FOXP2 bound to DNA.Semantic proximity Read

Different molecular complexes that mediate transcriptional induction and repression by FoxP3.Semantic proximity Read

Multidomain Coupling Governs FoxP1 Assembly and Nuclear CompartmentalizationSemantic proximity Read

Microfluidic affinity and ChIP-seq analyses converge on a conserved FOXP2-binding motif in chimp and human, which enables the detection of evolutionarily novel targets.Semantic proximity Read

FOXP3 recognizes microsatellites and bridges DNA through multimerization.Semantic proximity Read

TF-MAPS: fast high-resolution functional and allosteric mapping of DNA-binding proteinsSemantic proximity Read

FoxP3 recognizes microsatellites and bridges DNA through multimerizationSemantic proximity Read

A comprehensive in silico analysis of the deleterious nonsynonymous SNPs of human FOXP2 protein.Semantic proximity Read

A structure-guided approach to non-coding variant evaluation for transcription factor binding using AlphaFold 3Semantic proximity Read

FoxP3 can fold into two distinct dimerization states with divergent functional implications for T cell homeostasisSemantic proximity Read

A de novo FOXP1 variant in a patient with autism, intellectual disability and severe speech and language impairment.Semantic proximity Read