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Article

iRegNet3D: three-dimensional integrated regulatory network for the genomic analysis of coding and non-coding disease mutations.

Genome biology - 18 Jan 2017

Liang Siqi, Tippens Nathaniel D, Zhou Yaoda, Mort Matthew, Stenson Peter D, Cooper David N, Yu Haiyuan

Abstract excerpt

The mechanistic details of most disease-causing mutations remain poorly explored within the context of regulatory networks. We present a high-resolution three-dimensional integrated regulatory network (iRegNet3D) in the form of a web tool, where we resolve the interfaces of all known transcription factor (TF)-TF, TF-DNA and chromatin-chromatin interactions for the analysis of both coding and non-coding...

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Identifiers

PMID: 28100260
DOI: 10.1186/s13059-016-1138-2
PMCID: PMC5241969

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