Article

Designing Cell-Type-Specific Promoter Sequences Using Conservative Model-Based Optimization

2024-06-23

Abstract excerpt

Gene therapies have the potential to treat disease by delivering therapeutic genetic cargo to disease-associated cells. One limitation to their widespread use is the lack of short regulatory sequences, or promoters, that differentially induce the expression of delivered genetic cargo in target cells, minimizing side effects in other cell types. Such cell-type-specific promoters are difficult to discover using exis...

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Literature Corpus work: 15050884-a702-5d41-a2c4-017efc42c54c
DOI: 10.1101/2024.06.23.600232

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