Article

Directed evolution of compact synthetic promoters via AlphaGenome and genetic algorithms

2026-07-01

Abstract excerpt

<h4>ABSTRACT</h4> Compact tissue-specific promoters are highly desirable for gene therapy because viral vectors possess limited packaging capacity. However, existing promoter engineering strategies rely primarily on rational design or de novo sequence generation and lack efficient approaches for compressing long native promoters while preserving regulatory specificity. Although genome foundation models have subst...

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Literature Corpus work: a9304d64-dc44-57d5-b9e1-fc58592af94d
DOI: 10.64898/2026.06.28.735069

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