Article

Phenotype-driven de novo molecular design from gene expression signatures

2026-07-24

Abstract excerpt

<h4> A bstract </h4> Target-based and structure-guided drug design remain central to modern drug discovery, but complementary strategies are needed when predefined targets or binding pockets do not fully capture disease biology. Gene-expression signatures provide scalable system-level readouts of disease and perturbation states, making them attractive inputs for phenotype-guided molecular design. However, prese...

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Literature Corpus work: 26290b94-86e1-5216-ac7a-eeabc7efc221
DOI: 10.64898/2026.07.21.739736

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