Article

Strategies for effectively modelling promoter-driven gene expression using transfer learning

2023-02-27

Abstract excerpt

The ability to deliver genetic cargo to human cells is enabling rapid progress in molecular medicine, but designing this cargo for precise expression in specific cell types is a major challenge. Expression is driven by regulatory DNA sequences within short synthetic promoters, but relatively few of these promoters are cell-type-specific. The ability to design cell-type-specific promoters using model-based optimiza...

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Literature Corpus work: c260959e-b7df-573d-9943-4f4143206011
DOI: 10.1101/2023.02.24.529941

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