Article

Context-specific synthetic T cell promoters from assembled transcriptional elements

2023-10-17

Abstract excerpt

<title>Abstract</title> <p>Genetic engineering of human lymphocytes for therapeutic applications is constrained by a lack of transgene transcriptional control, resulting in a compromised therapeutic index. Incomplete understanding of transcriptional logic limits the rational design of contextually responsive genetic modules<sup>1</sup>. Here, we juxtaposed rationally curated transcriptional response element (TRE)...

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Literature Corpus work: 48d348db-7025-539c-b206-0fb6320a8170
DOI: 10.21203/rs.3.rs-3339290/v1

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