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Expression-linked promoter selection (ELiPS) engineers short, strong ubiquitous promoters for gene therapy applications

2026-06-26

Abstract excerpt

Adeno-associated virus (AAV)-based gene therapy has made steady progress towards efficient delivery to numerous target cell populations, yet the virus’s 5 kb packaging limit remains a challenge for effective and in some cases cell-selective cargo expression. Here, we introduce Expression-Linked Promoter Selection (ELiPS), a high-throughput platform for generating and functionally screening >10 6 engineered, short...

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Literature Corpus work
d79789fc-f200-5ac3-bd80-5d279173b009
DOI
10.64898/2026.06.25.734611
Open publication

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Expression-linked promoter selection (ELiPS) engineers short, strong ubiquitous promoters for gene therapy applicationsDOI 10.64898/2026.06.25.734611
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