Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems.

Nature communications - 12 Jan 2021

Yu Timothy C, Liu Winnie L, Brinck Marcia S, Davis Jessica E, Shek Jeremy, Bower Grace, Einav Tal, Insigne Kimberly D, Phillips Rob, Kosuri Sriram, Urtecho Guillaume

Abstract excerpt

A crucial step towards engineering biological systems is the ability to precisely tune the genetic response to environmental stimuli. In the case of Escherichia coli inducible promoters, our incomplete understanding of the relationship between sequence composition and gene expression hinders our ability to predictably control transcriptional responses. Here, we profile the expression dynamics of 8269 rationally...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biophysical Phenomena
Share to DNA-Directed RNA Polymerases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescence

Share to Genes, Reporter

Share to Isopropyl Thiogalactoside

Share to Operator Regions, Genetic

Share to Reproducibility of Results

Share to Thermodynamics

Source

Open in PubMed Open full text

Identifiers

PMID: 33436562
DOI: 10.1038/s41467-020-20094-3
PMCID: PMC7804116

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems.PMID 33436562Read ↗

Reliable prediction of complex phenotypes from a modular design in free energy space: an extensive exploration of the lac operon.Semantic proximity Read ↗

Promoter architecture dictates cell-to-cell variability in gene expression.Semantic proximity Read ↗

Non-transcriptional regulatory processes shape transcriptional network dynamics.Semantic proximity Read ↗

Predictive design of sigma factor-specific promoters.Semantic proximity Read ↗

Synthetic gene regulatory networks in the opportunistic human pathogen <i>Streptococcus pneumoniae</i>Semantic proximity Read ↗

Predicting bacterial promoter function and evolution from random sequences.Semantic proximity Read ↗

Engineering an allosteric transcription factor to respond to new ligands.Semantic proximity Read ↗

Plasmid-borne prokaryotic gene expression: sources of variability and quantitative system characterization.Semantic proximity Read ↗

Open-Source High-Throughput Phenomics of Bacterial Promoter-Reporter Strains.Semantic proximity Read ↗

Reconciling Kinetic and Equilibrium Models of Bacterial TranscriptionSemantic proximity Read ↗

Synthetic tetracycline-inducible regulatory networks: computer-aided design of dynamic phenotypes.Semantic proximity Read ↗

Comparison of the theoretical and real-world evolutionary potential of a genetic circuit.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.