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Article

Structure of the ER membrane complex, a transmembrane-domain insertase.

Nature - 1 Aug 2020

Bai Lin, You Qinglong, Feng Xiang, Kovach Amanda, Li Huilin

Abstract excerpt

The endoplasmic reticulum (ER) membrane complex (EMC) cooperates with the Sec61 translocon to co-translationally insert a transmembrane helix (TMH) of many multi-pass integral membrane proteins into the ER membrane, and it is also responsible for inserting the TMH of some tail-anchored proteins1-3. How EMC accomplishes this feat has been unclear. Here we report the first, to our knowledge, cryo-electron...

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Identifiers

PMID: 32494008
DOI: 10.1038/s41586-020-2389-3
PMCID: PMC7442705

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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