Article

Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism

2020-01-20

Abstract excerpt

<h4>ABSTRACT</h4> DHTKD1 is a lesser-studied E1 enzyme belonging to the family of 2-oxoacid dehydrogenases. DHTKD1, in complex with the E2 (dihydrolipoamide succinyltransferase, DLST) and E3 (lipoamide dehydrogenase, DLD) components, is implicated in lysine and tryptophan catabolism by catalysing the oxidative decarboxylation of 2-oxoadipate (2OA) in the mitochondria. Here, we solved the crystal structure of huma...

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Literature Corpus work: 06fc65d7-a2a5-5cc9-8c5b-e10ba44b9963
DOI: 10.1101/2020.01.20.912931

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