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Article

Cryo-EM structure of CtBP2 confirms tetrameric architecture.

Structure (London, England : 1993) - 1 Apr 2021

Jecrois Anne M, Dcona M Michael, Deng Xiaoyan, Bandyopadhyay Dipankar, Grossman Steven R, Schiffer Celia A, Royer William E

Abstract excerpt

C-terminal binding proteins 1 and 2 (CtBP1 and CtBP2) are transcriptional regulators that activate or repress many genes involved in cellular development, apoptosis, and metastasis. NADH-dependent CtBP activation has been implicated in multiple types of cancer and poor patient prognosis. Central to understanding activation of CtBP in oncogenesis is uncovering how NADH triggers protein assembly, what level of...

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Identifiers

PMID: 33264605
DOI: 10.1016/j.str.2020.11.008
PMCID: PMC9159756

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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