Article

The architecture of EMC reveals a path for membrane protein insertion

2020-05-16

Abstract excerpt

Approximately 25% of eukaryotic genes code for integral membrane proteins that are assembled at the endoplasmic reticulum. An abundant and widely conserved multi-protein complex termed EMC has been implicated in membrane protein biogenesis, but its mechanism of action is poorly understood. Here, we define the composition and architecture of human EMC using biochemical assays, crystallography of individual subunits...

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Literature Corpus work: 03ab26d6-1fb9-5f80-ba4a-ee1d37a802b5
DOI: 10.1101/2020.05.15.098574

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