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Article

SLAMF7 engagement super-activates macrophages in acute and chronic inflammation

2020-11-05

Abstract excerpt

Macrophages regulate protective immune responses to infectious microbes, but aberrant macrophage activation frequently drives pathological inflammation. To identify regulators of vigorous macrophage activation, we analyzed RNA-seq data from synovial macrophages and identified SLAMF7 as a receptor associated with a super-activated macrophage state in rheumatoid arthritis. We implicated IFN-γ as a key regulator of S...

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Identifiers and source

Literature Corpus work
14cf7960-e012-55d8-a9b9-015de20fa812
DOI
10.1101/2020.11.05.368647
Open publication

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SLAMF7 engagement super-activates macrophages in acute and chronic inflammationDOI 10.1101/2020.11.05.368647
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