Article
Monocyte and bone marrow macrophage transcriptional phenotypes in systemic juvenile idiopathic arthritis reveal TRIM8 as a mediator of IFN-γ hyper-responsiveness and risk for macrophage activation syndrome.
Annals of the rheumatic diseases - 1 May 2021
Schulert Grant S, Pickering Alex V, Do Thuy, Dhakal Sanjeev, Fall Ndate, Schnell Daniel, Medvedovic Mario, Salomonis Nathan, Thornton Sherry, Grom Alexei A
Abstract excerpt
OBJECTIVES: Systemic juvenile idiopathic arthritis (SJIA) confers high risk for macrophage activation syndrome (MAS), a life-threatening cytokine storm driven by interferon (IFN)-γ. SJIA monocytes display IFN-γ hyper-responsiveness, but the molecular basis of this remains unclear. The objective of this study is to identify circulating monocyte and bone marrow macrophage (BMM) polarisation phenotypes in SJIA...
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