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Article

Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1.

Cell communication and signaling : CCS - 15 May 2024

Zhu Li-Wen, Li Zihao, Dong Xiaohong, Wu Huadong, Cheng Yifan, Xia Shengnan, Bao Xinyu, Xu Yun, Cao Runjing

Abstract excerpt

BACKGROUND: Macrophages are key inflammatory immune cells that orchestrate the initiation and progression of autoimmune diseases. The characters of macrophage in diseases are determined by its phenotype in response to the local microenvironment. Ficolins have been confirmed as crucial contributors to autoimmune diseases, with Ficolin-2 being particularly elevated in patients with autoimmune diseases. However,...

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Identifiers

PMID: 38750493
DOI: 10.1186/s12964-024-01571-4
PMCID: PMC11094856

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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