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IFN- <i>γ</i> and TNF- <i>α</i> drive a <i>CXCL10</i> + <i>CCL2</i> + macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammation

2020-08-05

Abstract excerpt

Immunosuppressive and anti-cytokine treatment may have a protective effect for patients with COVID-19. Understanding the immune cell states shared between COVID-19 and other inflammatory diseases with established therapies may help nominate immunomodulatory therapies. Using an integrative strategy, we built a reference by meta-analyzing > 300,000 immune cells from COVID-19 and 5 inflammatory diseases including rhe...

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Literature Corpus work
02033ba7-31de-5032-bd04-69433edb5a64
DOI
10.1101/2020.08.05.238360
Open publication

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IFN- <i>γ</i> and TNF- <i>α</i> drive a <i>CXCL10</i> + <i>CCL2</i> + macrophage phenotype expanded in severe COVID-19 and other diseases with tissue inflammationDOI 10.1101/2020.08.05.238360
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