Article

IRF7 orchestrates proinflammatory macrophage polarization and joint destruction in rheumatoid arthritis

2025-09-24

Abstract excerpt

<title>Abstract</title> <p> <bold>Objectives</bold> Rheumatoid arthritis (RA) involves synovial inflammation driven by pathogenic macrophages, whose polarization is regulated by transcription factors (TFs). Interferon regulatory factor 7 (IRF7) is an innate immune regulator, but its role in RA macrophage-mediated inflammation and cartilage destruction remains unclear. This study aimed to define IRF7-dependent r...

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Literature Corpus work: eaf52ce8-dbc8-5224-88e9-d76a62077533
DOI: 10.21203/rs.3.rs-7536100/v1

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