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Article

IFN-γ and TNF-α drive a CXCL10+ CCL2+ macrophage phenotype expanded in severe COVID-19 lungs and inflammatory diseases with tissue inflammation.

Genome medicine - 20 Apr 2021

Zhang Fan, Mears Joseph R, Shakib Lorien, Beynor Jessica I, Shanaj Sara, Korsunsky Ilya, Nathan Aparna, Donlin Laura T, Raychaudhuri Soumya

Abstract excerpt

BACKGROUND: Immunosuppressive and anti-cytokine treatment may have a protective effect for patients with COVID-19. Understanding the immune cell states shared between COVID-19 and other inflammatory diseases with established therapies may help nominate immunomodulatory therapies. METHODS: To identify cellular phenotypes that may be shared across tissues affected by disparate inflammatory diseases, we developed a...

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Bronchoalveolar Lavage Fluid
Colitis, Ulcerative
Colon
Crohn Disease
Lung Diseases, Interstitial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Lupus Erythematosus, Systemic

Source

Open in PubMed Open full text

Identifiers

PMID: 33879239
DOI: 10.1186/s13073-021-00881-3
PMCID: PMC8057009

Genes

TNF
CCL2
CXCL10
CCL3
CXCL9
GBP1
IL1B
STAT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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