Article

GWAS of stool frequency reveals genes, pathways, and cell types relevant to human gastrointestinal motility and irritable bowel syndrome

2020-06-19

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Objective</h4> Gut dysmotility is associated with constipation, diarrhea, and functional gastrointestinal disorders (FGID) like irritable bowel syndrome (IBS). Its molecular underpinnings, and their anomalies in FGID disorders are poorly characterized, hence we sought to gain mechanistic insight through a large-scale genetic investigation. <h4>Design</h4> We used stool frequency (STL-FRQ) as...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 6cf1714e-f3f1-50c0-975d-0f9051fe9e90
DOI: 10.1101/2020.06.17.20132555

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

GWAS of stool frequency reveals genes, pathways, and cell types relevant to human gastrointestinal motility and irritable bowel syndromeDOI 10.1101/2020.06.17.20132555Read

Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility.Semantic proximity Read

Genetics of irritable bowel syndrome: shifting gear via biobank-scale studies.Semantic proximity Read

Genome-wide association study of gastrointestinal disorders reinforces the link between the digestive tract and the nervous systemSemantic proximity Read

Rome III Criteria Capture Higher Irritable Bowel Syndrome SNP-Heritability and Highlight a Novel Genetic Link With Cardiovascular Traits.Semantic proximity Read

Genetic epidemiology of irritable bowel syndrome.Semantic proximity Read

Combined GWAS and single cell transcriptomics uncover the underlying genes and cell types in disorders of gut-brain interactionSemantic proximity Read

Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845 492 individuals: a diagnostic studySemantic proximity Read

150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibilitySemantic proximity Read

Genome-wide multi-trait analysis of irritable bowel syndrome and related mental conditions identifies 38 new genetic hitsSemantic proximity Read

Irritable bowel syndrome-diarrhea: characterization of genotype by exome sequencing, and phenotypes of bile acid synthesis and colonic transit.Semantic proximity Read

Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohortsSemantic proximity Read

Genes and functional GI disorders: from casual to causal relationship.Semantic proximity Read