Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.

doi:10.1038/s41588-021-00950-8

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Genome-wide analysis of 53,400 people with irritable bowel syndrome highlights shared genetic pathways with mood and anxiety disorders.

Nature genetics - 1 Nov 2021

Eijsbouts Chris, Zheng Tenghao, Kennedy Nicholas A, Bonfiglio Ferdinando, Anderson Carl A, Moutsianas Loukas, Holliday Joanne, Shi Jingchunzi, Shringarpure Suyash, Voda Alexandru-Ioan, Farrugia Gianrico, Franke Andre, Hübenthal Matthias, Abecasis Gonçalo, Zawistowski Matthew, Skogholt Anne Heidi, Ness-Jensen Eivind, Hveem Kristian, Esko Tõnu, Teder-Laving Maris, Zhernakova Alexandra, Camilleri Michael, Boeckxstaens Guy, Whorwell Peter J, Spiller Robin, McVean Gil, D'Amato Mauro, Jostins Luke, Parkes Miles

Abstract excerpt

Irritable bowel syndrome (IBS) results from disordered brain-gut interactions. Identifying susceptibility genes could highlight the underlying pathophysiological mechanisms. We designed a digestive health questionnaire for UK Biobank and combined identified cases with IBS with independent cohorts. We conducted a genome-wide association study with 53,400 cases and 433,201 controls and replicated significant...

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PMID: 34741163
DOI: 10.1038/s41588-021-00950-8
PMCID: PMC8571093

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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