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Systematic analyses of GWAS summary statistics from UK Biobank identified novel susceptibility loci and genes for upper gastrointestinal diseases.

Journal of human genetics - 1 Sept 2023

Han Renfang, Huang Junxiang, Zeng Nimei, Xie Fangfei, Wang Yi, Wang Yun, Fan Jingyi

Abstract excerpt

In recent decades, upper gastrointestinal (GI) diseases have been highly prevalent worldwide. Although genome-wide association studies (GWASs) have identified thousands of susceptibility loci, only a few of them were conducted for chronic upper GI disorders, and most of them were underpowered and with small sample sizes. Additionally, for the known loci, only a tiny fraction of heritability can be explained and...

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PMID: 37198407
DOI: 10.1038/s10038-023-01151-3

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