Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibility

5 Jun 2023

Abstract excerpt

We conducted a genome-wide association study (GWAS) analysis of diverticular disease (DivD) of intestine within 724,372 individuals and identified 150 independent genome-wide significant DNA variants. Integration of the GWAS results with human gut single-cell RNA sequencing data implicated gut myocyte, mesothelial and stromal cells, and enteric neurons and glia in DivD development. Ninety-five genes were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Congenital gastrointestinal and neural anomalies
Share to Gastrointestinal disorders and treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 37492107
DOI: 10.1016/j.xgen.2023.100326

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

150 risk variants for diverticular disease of intestine prioritize cell types and enable polygenic prediction of disease susceptibilityPMID 37492107Read ↗

Genetic and transcriptomic landscape of colonic diverticulosis.Semantic proximity Read ↗

Genome-wide association analyses identify 39 new susceptibility loci for diverticular disease.Semantic proximity Read ↗

Diverticular disease genome-wide association meta-analysis identifies 257 novel loci, implicates structure and motilitySemantic proximity Read ↗

Genome-wide association study of gastrointestinal disorders reinforces the link between the digestive tract and the nervous systemSemantic proximity Read ↗

Combined GWAS and single cell transcriptomics uncover the underlying genes and cell types in disorders of gut-brain interactionSemantic proximity Read ↗

GWAS of stool frequency reveals genes, pathways, and cell types relevant to human gastrointestinal motility and irritable bowel syndromeSemantic proximity Read ↗

Genetic, epigenetic and environmental factors in diverticular disease: systematic review.Semantic proximity Read ↗

Unraveling the genetic susceptibility of irritable bowel syndrome: integrative genome-wide analyses in 845 492 individuals: a diagnostic studySemantic proximity Read ↗

Shared genetic susceptibilities for irritable bowel syndrome and depressive disorder in Chinese patients uncovered by pooled whole-exome sequencingSemantic proximity Read ↗

Unveiling Shared Genetic Architectures and Causality: Intestinal Diseases and Neurological Diseases.Semantic proximity Read ↗

Systematic analyses of GWAS summary statistics from UK Biobank identified novel susceptibility loci and genes for upper gastrointestinal diseases.Semantic proximity Read ↗

Multi-ancestry Genome- and Phenome-wide Association Studies of Diverticular Disease in Electronic Health Records with Natural Language Processing enriched phenotype algorithmSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.