Article

Nanoparticle-mediated delivery of peptide-based degraders enables targeted protein degradation

2024-03-19

Abstract excerpt

<h4>ABSTRACT</h4> The development of small molecule-based degraders against intracellular protein targets is a rapidly growing field that is hindered by the limited availability of high-quality small molecule ligands that bind to the target of interest. Despite the feasibility of designing peptide ligands against any protein target, peptide-based degraders still face significant obstacles such as, limited serum s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 38d273e4-4812-563c-a102-44bc302f5c42
DOI: 10.1101/2024.03.17.584721

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Nanoparticle-mediated delivery of peptide-based degraders enables targeted protein degradationDOI 10.1101/2024.03.17.584721Read

Nanoparticle-mediated delivery of peptide-based degraders enables targeted protein degradationSemantic proximity Read

Programmable protein degraders enable selective knockdown of pathogenic β-catenin subpopulations <i>in vitro</i> and <i>in vivo</i>Semantic proximity Read

Development of folate receptor targeting chimeras for cancer selective degradation of extracellular proteinsSemantic proximity Read

Cancer Selective Target Degradation by Folate-Caged PROTACsSemantic proximity Read

Trim-Away in adult animals through Nano-ERASER and its application in cancer therapySemantic proximity Read

Proteolysis‐targeting chimeras in drug development: A safety perspectiveSemantic proximity Read

Polymeric Lysosomal-Targeting Chimeras: Extracellular Targeted Protein Degradation Without Co-opting Lysosome-Targeting ReceptorsSemantic proximity Read

Clinical Translation of Targeted Protein DegradersSemantic proximity Read

Covalently Engineered Nanobody Chimeras for Targeted Membrane Protein DegradationSemantic proximity Read

Targeted protein degradation in oncology: novel therapeutic opportunity for solid tumours?Semantic proximity Read

Targeted Protein Degradation via NanoparticlesSemantic proximity Read

Cetuximab-based PROteolysis targeting chimera for effectual downregulation of NSCLC with varied EGFR mutations.Semantic proximity Read