Article
Acetyl-CoA synthetase mutations affect the susceptibility of Plasmodium falciparum to antimalarial drugs.
Microbiology spectrum - 7 Oct 2025
Zhao Wei, Xiang Zheng, Zeng Weilin, Qin Yucheng, Pan Maohua, Wu Yanrui, Duan Mengxi, Mou Ye, Liang Tao, Zhang Yanmei, Liu Cheng, Tang Xiuya, Huang Yaming, Yang Gongchao, Cui Liwang, Yang Zhaoqing
Abstract excerpt
Plasmodium falciparum acetyl-CoA synthetase (PfAcAS) is an important source of acetyl-CoA. We detected mutations S868G and V950I in PfAcAS by whole-genome sequencing analysis in certain recrudescent parasites after treatment with artesunate and dihydroartemisinin-piperaquine. Using CRISPR/Cas9 technology, we engineered parasite lines to carry the PfAcAS S868G and V950I mutations in two genetic backgrounds and...
Read the complete abstract on PubMedTopics
- Plasmodium falciparum
- Antimalarials
- Artemisinins
- Drug Resistance
- Mutation
- Malaria, Falciparum