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Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention

3 Aug 2021

Abstract excerpt

We identify the Plasmodium falciparum acetyl-coenzyme A synthetase (PfAcAS) as a druggable target, using genetic and chemical validation. In vitro evolution of resistance with two antiplasmodial drug-like compounds (MMV019721 and MMV084978) selects for mutations in PfAcAS. Metabolic profiling of compound-treated parasites reveals changes in acetyl-CoA levels for both compounds. Genome editing confirms that...

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PMID: 34348113
DOI: 10.1016/j.chembiol.2021.07.010

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