Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutational processes in cancer preferentially affect binding of particular transcription factors.

Scientific reports - 8 Feb 2021

Liu Mo, Boot Arnoud, Ng Alvin W T, Gordân Raluca, Rozen Steven G

Abstract excerpt

Protein binding microarrays provide comprehensive information about the DNA binding specificities of transcription factors (TFs), and can be used to quantitatively predict the effects of DNA sequence variation on TF binding. There has also been substantial progress in dissecting the patterns of mutations, i.e., the "mutational signatures", generated by different mutational processes. By combining these two layers...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinogenesis
Share to TF gene
Share to Models, Biological

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Neoplasm Proteins

Share to Neoplasms

Share to Response Elements

Share to Transcription Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 33558557
DOI: 10.1038/s41598-021-82910-0
PMCID: PMC7870974

Genes

TF
NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutational processes in cancer preferentially affect binding of particular transcription factors.PMID 33558557Read ↗

Impact of cancer mutational signatures on transcription factor motifs in the human genomeSemantic proximity Read ↗

A Robust Framework for Predicting Mutation Effects on Transcription Factor Binding: Insights from Mutational Signatures in 560 Breast Cancer GenomesSemantic proximity Read ↗

A Robust Framework for Predicting Mutation Effects on Transcription Factor Binding: Insights from Mutational Signatures in 560 Breast Cancer GenomesSemantic proximity Read ↗

Cis-regulatory somatic mutations and gene-expression alteration in B-cell lymphomas.Semantic proximity Read ↗

Network-based approaches elucidate differences within APOBEC and clock-like signatures in breast cancerSemantic proximity Read ↗

Accurate and sensitive mutational signature analysis with MuSiCalSemantic proximity Read ↗

Mutational Biases Drive Elevated Rates of Substitution at Regulatory Sites across Cancer Types.Semantic proximity Read ↗

Accurate and sensitive mutational signature analysis with MuSiCal.Semantic proximity Read ↗

A data-driven approach for constructing mutation categories for mutational signature analysis.Semantic proximity Read ↗

Divergence of mutational signatures in association with breast cancer subtype.Semantic proximity Read ↗

A framework for mutational signature analysis based on DNA shape parametersSemantic proximity Read ↗

Systematic analysis of somatic mutations impacting gene expression in 12 tumour types.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.